Three months after the events of Resident Evil 2, Claire Redfield is still looking for her brother Chris. She infiltrates Umbrella Corporation's headquarters in Paris, where she is captured and knocked out. When she comes to, she finds herself in a prison on a remote island. Freed by a friendly guard, Claire faces several problems. Not only is the island under attack by an unknown assailant, but there has been another outbreak of the T-Virus and the island is crawling with zombies and other mutated creatures. Claire not only has to face the undead, but also the commander of the base, a mad aristocrat with family ties to the origins of Umbrella Corporation and the T-Virus. And escaping from the island is only the beginning of Claire's ordeals.